Emily Huebner, MS
7/19/2021 09:35:14 pm
Thank you for watching! Please reply with any comments or questions and I'll respond as soon as I can. Happy #ICGBS week!
Group B Strep International
7/19/2021 10:35:16 pm
Thank you for such clear explanations of the very impressive work you are doing to better understand how GBS goes from an asymptomatic colonizer to an infectious pathogen. Appreciate all you are doing to improve pregnancy outcomes! Happy #ICGBS week to you, too!
7/20/2021 08:29:28 am
Love the analogies you used! I hope that all my patients can be adequately informed about GBS and I hope to use your explanation to aid in explaining potential outcomes and methods of infection to patients
7/22/2021 12:12:12 pm
That's so wonderful, thank you for your comment, Helena! I'm very glad this talk was beneficial in that way.
7/20/2021 09:50:04 am
Brilliant! Thanks . Do “NETS” play a role in impairing blood/nutrient flow in the placenta ? Do virulence factors act synergistically or additively?Are there local microbial (enzymes etc) or maternal( lymphatic, counter-current or iatrogenic factors that influence outcomes? Who was Theo bold Smith?
7/22/2021 12:11:20 pm
Hi James, thank you for these questions! I'll break up the answers to keep it clear.
7/21/2021 01:30:49 pm
I'm a parent and I want to thank you for taking the time to present this information because I now have a better understanding of how my daughter might've gotten GBS. When I found out she had GBS I had lots of questions and it wasn't until I found this website that I started getting answers and understanding. Your work means a lot to so many! Thank you <3
7/22/2021 11:57:02 am
Hi Shayna, your comment means so much! I'm so glad this talk was helpful and informative. Working in research that's inspired by patients and families is what makes me want to work that much harder to find solutions and improve care!
7/22/2021 09:34:58 am
Thank you for your research and presentation! Do you have any insight as to whether or not the presence of a mucous plug would significantly alter or slow down invasion of the amniotic cavity?
7/22/2021 11:54:26 am
Hi Marti, that's a great question! The cervical mucus plug has been studied a fair bit in ascending GBS infections because it really is this physical barrier that GBS has to sneak past. There was a great paper from 2018 that was written by Dr. Jay Vornhagen, who collaborated with the same collaborators I work with, the Rajagopal lab at Seattle Children's. The link to the paper is below, but one of their conclusions was that the mucus plug itself isn't bactericidal, but it can retain antibiotics in its cells and induce a neutrophil response to fight GBS, but further testing is needed to understand it's active role in allowing/preventing ascending infections.
7/22/2021 05:30:18 pm
Thank you for your answer and the link to that very interesting article!
7/22/2021 10:04:18 am
Have you noted any difference in virulence factors when moms experience vaginitis symptoms possibly from GBS? Or when moms have GBS in their urine?
7/22/2021 11:41:11 am
Hi Megan! That's a really interesting question. Our bacterial isolates were obtained from blood, vaginal swabs, and joint aspirations, we didn't have any urine samples to test. That would be a great next step for our research, however!
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