Prenatal-onset GBS Disease

Also on this page: Membrane Stripping & Preterm Labor

Learn more about the many types of prenatal infections and how to help prevent them!

Learn about Prenatal-onset Group B Strep Disease and earn CME credit, too! Visit the POGBSD symposium page!

Prenatal-onset GBS (POGBS) Disease
includes miscarriages and stillbirths caused by group B strep.

Currently, babies who are born already infected with group B strep are classified as "early-onset" regardless of when the infection began. According to a 2012 study done by Tudela and colleagues, "We hypothesize that these data support the concept that early-onset GBS represents a spectrum of infection that often precedes birth."

GBSI advocates that the timing of when the infection began should determine if a baby had early-onset vs. prenatal-onset GBS disease. (Please see Table 1 for Proposed Working Definitions of Prenatal-onset Group B Strep Disease.) This is important as early-onset prevention strategies don't prevent GBS infections beginning before a woman's labor starts or her water breaks. In looking at individual cases, did the early-onset strategy fail or could something different have been done to protect a particular baby?

According to the CDC 2010 MMWR, "The burden of prenatal-onset GBS disease has not been assessed adequately and no effective prevention tools have been identified before the intrapartum period." However, following are several knowledge-based strategies which may help prevent unborn babies becoming infected by group B strep or other harmful microorganisms:

1) Urine culturing for GBS and other bacteria
In the US, this is usually done at the first prenatal visit and is different than the standard prenatal urine “dipstick” check.

Urine culturing is important because having GBS in your urine means that you are likely to be heavily colonized vaginally where GBS could potentially harm your baby. You may have GBS in your urine without having any symptoms, but see your provider promptly if you do have any symptoms of a bladder (urinary tract) infection.

Ask about the results of your urine culture:

If you have a significant level of GBS in your urine or any symptoms, your provider should prescribe oral antibiotics at the time of diagnosis. GBSI advocates a recheck (“test of cure”) one month after treatment.
If you have any reportable amount of GBS in your urine, you should receive IV antibiotics for GBS during labor and delivery regardless of any future GBS test results in this pregnancy.

2) See your provider promptly for an exam if you have any “vaginitis” symptoms
GBS can cause vaginitis symptoms such as:

external vaginal burning
external vaginal irritation
unusual discharge

These symptoms may be mistaken for a yeast infection and treated incorrectly. Read studies about Vaginitis & GBS HERE.

3) Avoid unnecessary invasive procedures
Invasive procedures may push GBS closer to your baby where GBS is able to cross intact membranes. Knowing how far you are dilated does not accurately predict when your baby will be born. Vaginal or perineal ultrasounds are less invasive options for internal exams although may not be readily available in all health care settings.

In the 201o CDC MMWR, on pg 7, the CDC discusses GBS and it's ability to cross intact amniotic membranes.

“GBSI’s Information Statement on Fetal Membrane Stripping” (en español) (en français) explains why membrane stripping (or “sweeping”) should be avoided.

“Do Not Strip Membranes in the Presence of Group B Strep and Here’s Why” by Dr. James A. McGregor. This video contains ultrasound footage illustrating active uterine transport in both a non-pregnant and pregnant patient.

Video testimonials by providers as to why they avoid stripping membranes can be viewed on GBSI’s YouTube channel.

GBSI’s advocacy poster “Membranes should NOT be stripped” below (en español) explains why membranes should NOT be stripped even if a woman tests negative for GBS! It is important to know that E. coli and other local microflora can also cross/weaken intact membranes.

GBSI advocates for informed consent prior to membrane stripping. Click HERE for our sample Learning Consent Form

Please click HERE for medical abstracts on the risk of infection due to invasive procedures.

4) Know the signs of infection in unborn babies!

Reasons to contact your provider immediately:

Decreased or no fetal movement after your 20th week
You have any unexplained fever

GBS can also cause preterm labor and premature rupture of membranes, causing your baby to be born too early.

It's important to know the warning signs and symptoms of preterm labor. Call your health care provider right away if you experience any of the following: