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The changing epidemiology of GBS urogenital infections: focus on diabetes and obesity

7/19/2021

 
Ryan Doster, MD, PhD
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Ryan Doster, MD, PhD
About presenter
Ryan Doster is an Assistant Professor of Clinical Medicine in the Division of Infectious Diseases at Vanderbilt University Medical Center. He earned a B.A. from Hanover College (Hanover IN) before attending Indiana University School of Medicine. Following completion of his medical degree, Dr. Doster completed a combined residency in Internal Medicine and Pediatrics at Indiana University School of Medicine. He then completed subspecialty training in adult infectious diseases medicine at Vanderbilt University Medical Center (Nashville TN). During his fellowship, Dr. Doster completed a Ph.D. in Microbe-Host Interactions, where his research focused on interactions between GBS and innate immune cells within the female reproductive tract. His current research program examines how host diet and nutrition might impact GBS vaginal colonization and perinatal infections.
Group B Strep International
7/19/2021 09:50:33 pm

Thank you so much, Dr. Doster, for your excellent presentation on maternal obesity and diabetes in regards to GBS colonization and infection. We so appreciate all you do to promote healthy pregnancy outcomes!

Ryan Doster
7/20/2021 06:19:11 am

It is my pleasure to take part in this great event. Thank you for inviting me to share some of our work!

William Maller
7/20/2021 10:23:48 am

Thank you, thorough talk

Marti Perhach
7/20/2021 10:36:39 am

Thank you for your very clear explanations of the studies you noted. Do you have any insight as to whether or not the risk of GBS colonization increases as a woman gains weight throughout her pregnancy, whether a normal pregnancy weight gain or an excessive amount?

Ryan Doster
7/20/2021 04:14:19 pm

It is an excellent question. I do not think we know the answer at this time. Most of these studies separated women by BMI prior to pregnancy. I have not seen any studies examining the impact of excessive weight gain during pregnancy on GBS colonization.

Amelia P
7/20/2021 11:23:15 am

Could this issue be considered multigenerational as pregnant people who are obese are more likely to have children who become obese compounding this upwards trend?

Ryan Doster
7/20/2021 04:20:00 pm

This is an excellent point Amelia, and one of my biggest concerns. Both maternal diabetes and obesity increase risk that the child will then become obese. This perpetuating cycle from generation to generation may have a major impact on reproductive health in the future.

Tara Randis
7/20/2021 06:41:08 pm

Really nice talk Dr. Doster!

James Mcgregor
7/21/2021 06:45:06 pm

Masterful grand rounds! Will epigenetic /transgenerational mechanisms be involved? Hyper glycemic leading to Barker mechanisms?

Ryan Doster
7/22/2021 11:19:53 am

That is a great question. Ongoing work regarding the developmental origins of health suggest a link between perinatal exposures and metabolic syndrome later in life. As far as the interactions between those exposures, infection during that pregnancy or risk for future infections, i think that is an ongoing area of research. There are certainly studies that suggest that early exposures may "train" parts of the immune system which may impact risk for infections later in life.


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  • Home
  • About GBS
    • What Is Group B Strep? >
      • Prenatal-onset GBS Disease
      • Early-onset GBS Disease
      • Late-onset GBS Disease
      • GBS in Nonpregnant Adults
      • Maternal GBS Infections
    • How to Help Protect Your Baby >
      • How Do You Get GBS?
      • GBS Testing
      • Testing Negative
      • Subsequent Pregnancy
      • Risk Factors
    • Signs of GBS Infection
    • GBS Vaccine Efforts
  • Resources
    • GBS Awareness Materials
    • Online Learning Events >
      • GBS Community Days 2023
      • ICGBS 2022
      • ICGBS 2021
      • ICGBS 2020
      • ICGBS 2019
      • Prenatal Infection Prevention Symposium
      • POGBSD Symposium
    • Prenatal Infection Prevention Resources
    • GBS Medical Articles and Abstracts
    • GBS Parent Connection & Grief Support
  • Parent Stories
    • GBS Babies
    • Story Submission
    • Subsequent Pregnancies
    • Possible GBS Infections
    • Perinatal Infection Stories
  • WAYS TO HELP
    • Make a Donation
    • Fundraising
    • The WAVES Study
    • Campaigns & Projects
    • Awareness Calendar >
      • Group B Strep Awareness
      • Prenatal-onset GBS Disease Recognition Month
      • Prenatal Infection Prevention Month
    • Suggested Topics for Researchers
  • About Us
    • Our Mission
    • Our Board of Directors
    • Our Partners & Perinatal Health Affiliates
    • Fast Facts
    • Contact Us