Ryan Doster, MD, PhD
Group B Strep International
7/19/2021 09:50:33 pm
Thank you so much, Dr. Doster, for your excellent presentation on maternal obesity and diabetes in regards to GBS colonization and infection. We so appreciate all you do to promote healthy pregnancy outcomes!
7/20/2021 06:19:11 am
It is my pleasure to take part in this great event. Thank you for inviting me to share some of our work!
7/20/2021 10:23:48 am
Thank you, thorough talk
7/20/2021 10:36:39 am
Thank you for your very clear explanations of the studies you noted. Do you have any insight as to whether or not the risk of GBS colonization increases as a woman gains weight throughout her pregnancy, whether a normal pregnancy weight gain or an excessive amount?
7/20/2021 04:14:19 pm
It is an excellent question. I do not think we know the answer at this time. Most of these studies separated women by BMI prior to pregnancy. I have not seen any studies examining the impact of excessive weight gain during pregnancy on GBS colonization.
7/20/2021 11:23:15 am
Could this issue be considered multigenerational as pregnant people who are obese are more likely to have children who become obese compounding this upwards trend?
7/20/2021 04:20:00 pm
This is an excellent point Amelia, and one of my biggest concerns. Both maternal diabetes and obesity increase risk that the child will then become obese. This perpetuating cycle from generation to generation may have a major impact on reproductive health in the future.
7/20/2021 06:41:08 pm
Really nice talk Dr. Doster!
7/21/2021 06:45:06 pm
Masterful grand rounds! Will epigenetic /transgenerational mechanisms be involved? Hyper glycemic leading to Barker mechanisms?
7/22/2021 11:19:53 am
That is a great question. Ongoing work regarding the developmental origins of health suggest a link between perinatal exposures and metabolic syndrome later in life. As far as the interactions between those exposures, infection during that pregnancy or risk for future infections, i think that is an ongoing area of research. There are certainly studies that suggest that early exposures may "train" parts of the immune system which may impact risk for infections later in life.
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