Investigating mechanisms of persistent Group B Streptococcus colonization after intrapartum antibiotic prophylaxis treatment
Macy E. Pell, BS, PhD Candidate
Group B Strep International
7/21/2021 09:36:00 pm
Thank you for sharing the impressive work you are doing to study the mechanisms of persistent GBS colonization. Excellent presentation!
7/22/2021 08:50:48 am
Thank you! I'm grateful for the opportunity to present my preliminary work at ICGBS2021!
7/21/2021 10:46:42 pm
But in presentation two days back it has been said that IAP will reduce the late onset disease as well.
7/22/2021 09:11:24 am
Thank you for your comment! IAP has been shown to significantly reduce the incidence of early-onset neonatal disease. We have not seen a significant reduction in cases of late-onset neonatal disease since the implementation of IAP treatment policies. There is currently no effective treatment for late-onset neonatal disease; therefore, the efforts to improve treatment and prevention strategies for GBS are crucial.
7/22/2021 06:23:37 am
Hi Macy, congratulation for your impressive presentation and black cat.
7/22/2021 09:52:58 am
Thank you for your comment. Bubba the black cat has been an excellent co-worker while working remotely during the pandemic!
7/22/2021 03:30:11 pm
In your study were you aware of any instances of persistent colonization in women with vaginitis symptoms that may have been attributable to GBS? GBSI often hears from women with chronic and persistent vaginitis symptoms after multiple treatments.
7/22/2021 06:49:46 pm
Thank you for your question! I have not looked into whether these women experienced vaginitis symptoms. I'm not sure if the cohort study collected this information but I will be sure to look into it. Thanks for bringing this information to my attention!
James Mcgregor mdcm
7/22/2021 08:57:40 pm
Thanks for you eloquently explication of this leading foundational work.questions: what about biofilm production, presence of L- forms, other commensals that promoted Gbs survival,? Or presence anti- host response factors? IgA ases?
7/23/2021 12:00:07 pm
Thank you for your comment and questions! These factors were not extracted in my analyses but I am planning on performing some functional assays, possibly looking into biofilm formation as this may be a component of persistent colonization. In one of my other projects I am investigating the impact of certain commensal species on GBS growth and survival, this work is still in the preliminary stages, but do feel free to connect if you are interested in following this work!
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