Antibiotic adjuvants: rejuvenating our current arsenal of antimicrobials against Group B Streptococcus
Sabrina K. Spicer, BS, current PhD student
Group B Strep International
7/21/2021 10:02:07 pm
What an exceptional presentation on your intriguing study of antibiotic adjuvants as a way to help reduce antimicrobial resistance. Thank you for presenting for us at ICGBS 2021!
7/22/2021 02:59:10 am
7/22/2021 06:32:41 am
7/22/2021 06:45:15 am
Consider that LIM broth is an enrichment media for GBS identification in antenatal screening of pregnant women, used to inoculate the vaginal rectal swab. It contains gentamycin 8 micrograms/ml. This means in your opinion that then we can miss some GBS because they possess a lower gentamycin MIC?
7/22/2021 08:53:04 am
I was under the impression that LIM broth was supplemented with colostin, not gentamicin, which would ensure that GBS is still present in the swab. That being said, it is my opinion that if it was supplemented with gentamicin there is a possibility that it would kill GBS present, especially if the GBS that is being swabbed is not gentamicin resistant.
7/22/2021 09:51:48 am
Yes, LIM broth is Todd-Hewitt broth supplemented with 10µg/mL colistin or 8µg/mL gentamicin and 15µg/mL nalidixic acid. So, if there is gentamicin instead of colistin, it can represent a problem for GBS identification, can't it?
7/22/2021 03:36:59 pm
When used as adjuvants, could household medications cause the side effects associated with their normal use such as drowsiness with claritin?
James Mcgregor mdcm
7/22/2021 09:23:09 pm
Thanks for your clear ,concise description of your fascinating studies. Could the development of Sulbactam/ ampicillin (Unycin) or trimethaprim/ sulfa ( Septra)be useful in explaining the potential power of your approaches? This is very exciting work! How about substances like vitamins ( folate etc)?
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